PTEN (基因)

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磷酸酯酶與張力蛋白同源物

人PTEN的晶體結構圖。N-端磷酸酯酶結構域以藍色表示而C-端C2結構域以紅色表示[1]
有效結構
PDB 直系同源檢索:PDBe, RCSB
標識
代號 PTEN; 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
擴展標識 遺傳學601728 鼠基因109583 同源基因265 GeneCards: PTEN Gene
EC編號 3.1.3.48, 3.1.3.67|,%s*|+|plain=false}} 3.1.3.16, 3.1.3.48, 3.1.3.67
直系同源體
物種 人類 鼠類
Entrez 5728 19211
Ensembl ENSG00000171862 ENSMUSG00000013663
UniProt P60484 O08586
mRNA序列 NM_000314 NM_008960
蛋白序列 NP_000305 NP_032986
基因位置 Chr 10:
89.62 – 89.73 Mb
Chr 19:
32.76 – 32.83 Mb
PubMed查詢 [1] [2]
File:PTEN.png
PTEN蛋白(藍色)與酒石酸(棕色)複合的空間結構模型[1]

磷酸酯酶與張力蛋白同源英語:Phosphatase and tensin homolog,簡稱為PTEN)是一種在人體中由PTEN基因編碼的蛋白質[2]。該基因的突變是多種癌症進展過程的環節之一。

PTEN通過其磷酸酯酶蛋白產物而行使一種抑癌基因的作用。這一磷酸酯酶參與了細胞周期的調節,阻止細胞過快地生長與分裂[3]。其為癌微RNAMIRN21的靶之一。

該基因被鑒定為一種腫瘤抑制物,在多種癌症中往往處於變異狀態。該基因編碼的蛋白質是一種磷脂醯肌醇-3,4,5-三磷酸3-磷酸酯酶。該蛋白同時含有一張力蛋白結構域及一催化結構域,這與雙特異性蛋白酪氨酸磷酸酶很相似。但與大部分蛋白質酪氨酸磷酸酶不同的是,該蛋白偏好脫去磷酸肌醇底物上的磷酸。該蛋白負性調控胞內磷脂醯肌醇-3,4,5-三磷酸的水平,並通過負性調控Akt/PKB信號通道發揮抑癌基因的作用[4]

目錄

參考文獻

  1. 1.0 1.1 PDB 1d5rLee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. October 1999, 99 (3): 323–34. doi:10.1016/S0092-8674(00)81663-3. PMID 10555148. 
  2. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet.. April 1997, 15 (4): 356–62. doi:10.1038/ng0497-356. PMID 9090379. 
  3. Chu EC, Tarnawski AS. PTEN regulatory functions in tumor suppression and cell biology. Med. Sci. Monit.. October 2004, 10 (10): RA235–41. PMID 15448614. 
  4. Entrez Gene: PTEN phosphatase and tensin homolog (mutated in multiple advanced cancers 1). 

深入閱讀

  • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997, 275 (5308): 1943–1947. doi:10.1126/science.275.5308.1943. PMID 9072974. 
  • Simpson L, Parsons R. PTEN: life as a tumor suppressor. Exp Cell Res. 2001, 264 (1): 29–41. doi:10.1006/excr.2000.5130. PMID 11237521. 
  • Chu EC, Tarnawski AS. PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit. 2004, 10 (10): RA235–41. PMID 15448614. 
  • Eng C. PTEN: one gene, many syndromes. Hum Mutat. 2003, 22 (3): 183–98. doi:10.1002/humu.10257. PMID 12938083. 
  • Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1199575/ The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis]. Genes Dev. 2005, 19 (17): 2054–65. doi:10.1101/gad.1308805. PMID 16107612. PMC 1199575. 
  • Leslie NR, Downes CP. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1133909/ PTEN function: how normal cells control it and tumour cells lose it]. Biochem J. 2004, 382 (Pt 1): 1–11. doi:10.1042/BJ20040825. PMID 15193142. PMC 1133909. 
  • Pilarski R, Eng C. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1735782/ Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome]. J Med Genet. 2004, 41 (5): 323–6. doi:10.1136/jmg.2004.018036. PMID 15121767. PMC 1735782. 
  • Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004, 22 (14): 2954–63. doi:10.1200/JCO.2004.02.141. PMID 15254063. 
  • Waite KA, Eng C. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC379112/ Protean PTEN: Form and Function]. Am J Hum Genet. 2002, 70 (4): 829–44. doi:10.1086/340026. PMID 11875759. PMC 379112. 
  • Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ, Bos C, Dasouki M, Feldman GL, Greenberg LA, Ivanovich J, Matloff E, Patterson A, Pierpont ME, Russo D, Nassif NT, Eng C. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1180378/ Germline PTEN Promoter Mutations and Deletions in Cowden/Bannayan-Riley-Ruvalcaba Syndrome Result in Aberrant PTEN Protein and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway]. Am J Hum Genet. 2003, 73 (2): 404–11. doi:10.1086/377109. PMID 12844284. PMC 1180378. 
  • Ji S-P, Zhang Y, Cleemput JV, Jiang W, Liao M, Li L, Wan Q, Backstrom JR, Zhang X. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Nature Medicine. 2006, 12 (3): 324–9. doi:10.1038/nm1349. PMID 16474401. 

外部連結

PTEN (基因)引用了美國國家醫學圖書館提供的資料,這些資料屬於公共領域。

Template:蛋白酪氨酸磷酸酶類

參考來源

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