視網膜母細胞瘤蛋白

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A+醫學百科 >> 視網膜母細胞瘤蛋白
Retinoblastoma 1

PDB rendering based on 1ad6.
有效結構
PDB 直系同源檢索：PDBe, RCSB
標識
代號 RB1; OSRC; RB; p105-Rb; pRb; pp110
擴展標識 遺傳學：614041 鼠基因：97874 同源基因：272 ChEMBL: 5288 GeneCards: RB1 Gene
RNA表達模式
PBB GE RB1 203132 at.png
PBB GE RB1 211540 s at.png
更多表達數據
直系同源體
物種 人類 鼠類
Entrez 5925 19645
Ensembl ENSG00000139687 ENSMUSG00000022105
UniProt P06400 P13405
mRNA序列 NM_000321 NM_009029
蛋白序列 NP_000312 NP_033055
基因位置 Chr 13:
48.88 – 49.06 Mb		 Chr 14:
73.18 – 73.33 Mb
PubMed查詢 [1] [2]
This box:

視網膜母細胞瘤蛋白（英語：retinoblastoma protein，常縮寫為pRb、RB或RB1）又譯為成視網膜細胞瘤蛋白是一種抑癌蛋白，並在幾種主要的癌症發生時失活[1]。pRb的功能之一是通過抑制細胞周期進程直到細胞準備妥當來防止細胞過度生長。

pRb是袋狀蛋白家族的一員，其特點是有一個口袋狀的結構用以結合其它蛋白[2][3]。使得一些致癌變蛋白，比如高危險群人類乳突病毒所感染的細胞產生的蛋白，結合併抑制pRb，最終導致癌症。

目錄

相互作用

已知Rb蛋白與下列蛋白質有相互作用關係：

細胞凋亡中涉及的信號通路一覽

參考文獻

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  71. ↑ Vandel L, Nicolas E, Vaute O, Ferreira R, Ait-Si-Ali S, Trouche D. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC99795/ Transcriptional Repression by the Retinoblastoma Protein through the Recruitment of a Histone Methyltransferase]. Mol. Cell. Biol.. October 2001, 21 (19): 6484–94. doi:10.1128/MCB.21.19.6484-6494.2001. PMID 11533237. PMC 99795. 
  72. ↑ Shao Z, Ruppert S, Robbins PD. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC42115/ The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250]. Proc. Natl. Acad. Sci. U.S.A.. April 1995, 92 (8): 3115–9. doi:10.1073/pnas.92.8.3115. PMID 7724524. PMC 42115. 
  73. ↑ Siegert JL, Robbins PD. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC83941/ Rb Inhibits the Intrinsic Kinase Activity of TATA-Binding Protein-Associated Factor TAFII250]. Mol. Cell. Biol.. January 1999, 19 (1): 846–54. PMID 9858607. PMC 83941. 
  74. ↑ Shao Z, Siegert JL, Ruppert S, Robbins PD. Rb interacts with TAF(II)250/TFIID through multiple domains. Oncogene. July 1997, 15 (4): 385–92. doi:10.1038/sj.onc.1201204. PMID 9242374. 
  75. ↑ Durfee T, Mancini MA, Jones D, Elledge SJ, Lee WH. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2120229/ The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing]. J. Cell Biol.. November 1994, 127 (3): 609–22. doi:10.1083/jcb.127.3.609. PMID 7525595. PMC 2120229. 
  76. ↑ Chen CF, Chen Y, Dai K, Chen PL, Riley DJ, Lee WH. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC231469/ A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock]. Mol. Cell. Biol.. September 1996, 16 (9): 4691–9. PMID 8756626. PMC 231469. 
  77. ↑ Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC23019/ A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein]. Proc. Natl. Acad. Sci. U.S.A.. August 1997, 94 (17): 9040–5. doi:10.1073/pnas.94.17.9040. PMID 9256431. PMC 23019. 
  78. ↑ Hannan KM, Hannan RD, Smith SD, Jefferson LS, Lun M, Rothblum LI. Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. Oncogene. October 2000, 19 (43): 4988–99. doi:10.1038/sj.onc.1203875. PMID 11042686. 
  79. ↑ Blanchette P, Gilchrist CA, Baker RT, Gray DA. Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. Oncogene. September 2001, 20 (39): 5533–7. doi:10.1038/sj.onc.1204823. PMID 11571651. 

視網膜母細胞瘤蛋白引用了美國國家醫學圖書館提供的資料，這些資料屬於公共領域。


延伸閱讀

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  • Clemo NK, Arhel NJ, Barnes JD, et al.. The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. Biochem. Soc. Trans.. 2005, 33 (Pt 4): 676–8. doi:10.1042/BST0330676. PMID 16042572. 
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