表皮生長因子受體

Epidermal growth factor receptor; 表皮生長因子受體
	; 表皮生長因子受體的胞外結構域與表皮生長因子結合的複合體，引自PDB1nql
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2GS2, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITX, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0
標識
代號	EGFR; ERBB; ERBB1; HER1; PIG61; mENA
擴展標識	遺傳學：131550 鼠基因：95294 同源基因：74545 ChEMBL: 203 GeneCards: EGFR Gene
EC編號	2.7.10.1
基因本體論描述
分子功能	· double-stranded DNA binding; · MAP kinase kinase kinase activity; · protein tyrosine kinase activity; · transmembrane receptor protein tyrosine kinase activity; · receptor signaling protein tyrosine kinase activity; · transmembrane signaling receptor activity; · epidermal growth factor-activated receptor activity; · protein binding; · ATP binding; · enzyme binding; · protein phosphatase binding; · nitric-oxide synthase regulator activity; · identical protein binding; · protein heterodimerization activity; · actin filament binding;
細胞成分	· Golgi membrane; · extracellular space; · nucleus; · cytoplasm; · endosome; · endoplasmic reticulum membrane; · plasma membrane; · endosome membrane; · membrane; · integral to membrane; · basolateral plasma membrane; · AP-2 adaptor complex; · nuclear membrane; · membrane raft; · perinuclear region of cytoplasm; · Shc-EGFR complex;
生物過程	· MAPK cascade; · activation of MAPKK activity; · ossification; · embryonic placenta development; · hair follicle development; · response to stress; · signal transduction; · cell surface receptor signaling pathway; · epidermal growth factor receptor signaling pathway; · activation of phospholipase C activity; · axon guidance; · salivary gland morphogenesis; · cell proliferation; · positive regulation of cell proliferation; · fibroblast growth factor receptor signaling pathway; · cell-cell adhesion; · cerebral cortex cell migration; · positive regulation of cell migration; · positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S; · positive regulation of catenin import into nucleus; · negative regulation of epidermal growth factor receptor signaling pathway; · negative regulation of protein catabolic process; · positive regulation of phosphorylation; · activation of phospholipase A2 activity by calcium-mediated signaling; · negative regulation of apoptotic process; · positive regulation of MAP kinase activity; · innate immune response; · positive regulation of nitric oxide biosynthetic process; · positive regulation of DNA repair; · positive regulation of DNA replication; · protein autophosphorylation; · neurotrophin TRK receptor signaling pathway; · phosphatidylinositol-mediated signaling; · positive regulation of fibroblast proliferation; · digestive tract morphogenesis; · positive regulation of epithelial cell proliferation; · regulation of peptidyl-tyrosine phosphorylation; · regulation of nitric-oxide synthase activity; · protein insertion into membrane; · positive regulation of protein kinase B signaling cascade; · morphogenesis of an epithelial fold; · response to UV-A;
	Sources: Amigo / QuickGO
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A+醫學百科 >> 表皮生長因子受體

表皮生長因子受體（英語：epidermal growth factor receptor，簡稱為EGFR、ErbB-1或HER1）是一類名為表皮生長因子家族（EGF-家族）的細胞外蛋白配體的細胞表面受體^[2] 。

表皮生長因子受體是ErbB受體家族家族的成員之一，ErbB家族是包含四種緊密聯繫蛋白的亞家族，這四種蛋白分別是受體酪氨酸激酶類：EGFR（ErbB-1）HER2/c-neu（ErbB-2）、Her 3（ErbB-3）以及Her 4（ErbB-4）。影響EGFR表達或活性的突變可能導致癌症^[3]。

表皮生長因子及其受體是由范德堡大學的斯坦利·科恩發現的，科恩與麗塔·列維-蒙塔爾奇尼因發現生長因子類而共同獲得了1986年諾貝爾生理學或醫學獎。

功能

EGFR信號傳導級聯

表皮生長因子受體（EGFR）存在於細胞表面且因結合特異性受體而被激活，這些受體包括表皮生長因子和TGFα。ErbB2並無已知的直接激活配體，可能結構性地處於激活狀態，或在與如EGFR等其他家族成員形成異源二聚體時被激活。

參考文獻

↑ PMID 12620237（PubMed）
本引用來源將會在數十分鐘後自動完成。您可以檢查英文對應模板或手動擴充
↑ Herbst RS. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys.. 2004, 59 (2 Suppl): 21–6. doi:10.1016/j.ijrobp.2003.11.041. PMID 15142631.
↑ Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1934579/ ErbB receptors: from oncogenes to targeted cancer therapies]. J. Clin. Invest.. August 2007, 117 (8): 2051–8. doi:10.1172/JCI32278. PMID 17671639. PMC 1934579.

深入閱讀

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Boonstra J, Rijken P, Humbel B, et al.. The epidermal growth factor. Cell Biol. Int.. 1995, 19 (5): 413–30. doi:10.1006/cbir.1995.1086. PMID 7640657.
Carpenter G. The EGF receptor: a nexus for trafficking and signaling. BioEssays. 2000, 22 (8): 697–707. doi:10.1002/1521-1878(200008)22:8<697::AID-BIES3>3.0.CO;2-1. PMID 10918300.
Filardo EJ. Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. J. Steroid Biochem. Mol. Biol.. 2002, 80 (2): 231–8. doi:10.1016/S0960-0760(01)00190-X. PMID 11897506.
Tiganis T. Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor. IUBMB Life. 2002, 53 (1): 3–14. doi:10.1080/15216540210811. PMID 12018405.
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Benaim G, Villalobo A. Phosphorylation of calmodulin. Functional implications. Eur. J. Biochem.. 2002, 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.
Leu TH, Maa MC. Functional implication of the interaction between EGF receptor and c-Src. Front. Biosci.. 2004, 8 (1-3): s28–38. doi:10.2741/980. PMID 12456372.
Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol. Cell Proteomics. 2003, 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
Kari C, Chan TO, Rocha de Quadros M, Rodeck U. Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage. Cancer Res.. 2003, 63 (1): 1–5. PMID 12517767.
Bonaccorsi L, Muratori M, Carloni V, et al.. Androgen receptor and prostate cancer invasion. Int. J. Androl.. 2003, 26 (1): 21–5. doi:10.1046/j.1365-2605.2003.00375.x. PMID 12534934.
Reiter JL, Maihle NJ. Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta. Annals of the New York Academy of Sciences. 2003, 995 (1): 39–47. doi:10.1111/j.1749-6632.2003.tb03208.x. PMID 12814937.
Adams TE, McKern NM, Ward CW. Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor. Growth Factors. 2005, 22 (2): 89–95. doi:10.1080/08977190410001700998. PMID 15253384.
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外部連結

MeSH（醫學主題詞）上面的Epidermal Growth Factor Receptor

參考來源

維基百科-表皮生長因子受體

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