表皮生長因子受體

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Epidermal growth factor receptor
表皮生長因子受體

表皮生長因子受體的胞外結構域與表皮生長因子結合的複合體,引自PDB1nql[1]
有效結構
PDB 直系同源檢索:PDBe, RCSB
標識
代號 EGFR; ERBB; ERBB1; HER1; PIG61; mENA
擴展標識 遺傳學131550 鼠基因95294 同源基因74545 ChEMBL: 203 GeneCards: EGFR Gene
EC編號 2.7.10.1
RNA表達模式
PBB GE EGFR 201983 s at.png
更多表達數據
直系同源體
物種 人類 鼠類
Entrez 1956 13649
Ensembl ENSG00000146648 ENSMUSG00000020122
UniProt P00533 Q01279
mRNA序列 NM_005228 NM_007912
蛋白序列 NP_005219 NP_031938
基因位置 Chr 7:
55.09 – 55.32 Mb
Chr 11:
16.75 – 16.92 Mb
PubMed查詢 [1] [2]

表皮生長因子受體英語:epidermal growth factor receptor,簡稱為EGFRErbB-1HER1)是一類名為表皮生長因子家族(EGF-家族)的細胞蛋白配體細胞表面受體[2]

表皮生長因子受體是ErbB受體家族家族的成員之一,ErbB家族是包含四種緊密聯繫蛋白的亞家族,這四種蛋白分別是受體酪氨酸激酶類:EGFR(ErbB-1)HER2/c-neu(ErbB-2)、Her 3(ErbB-3)以及Her 4(ErbB-4)。影響EGFR表達或活性的突變可能導致癌症[3]

表皮生長因子及其受體是由范德堡大學的斯坦利·科恩發現的,科恩與麗塔·列維-蒙塔爾奇尼因發現生長因子類而共同獲得了1986年諾貝爾生理學或醫學獎

目錄

功能

EGFR信號傳導級聯

表皮生長因子受體(EGFR)存在於細胞表面且因結合特異性受體而被激活,這些受體包括表皮生長因子和TGFα。ErbB2並無已知的直接激活配體,可能結構性地處於激活狀態,或在與如EGFR等其他家族成員形成異源二聚體時被激活。

參考文獻

  1. PMID 12620237PubMed
    本引用來源將會在數十分鐘後自動完成。您可以檢查英文對應模板手動擴充
  2. Herbst RS. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys.. 2004, 59 (2 Suppl): 21–6. doi:10.1016/j.ijrobp.2003.11.041. PMID 15142631. 
  3. Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1934579/ ErbB receptors: from oncogenes to targeted cancer therapies]. J. Clin. Invest.. August 2007, 117 (8): 2051–8. doi:10.1172/JCI32278. PMID 17671639. PMC 1934579. 

深入閱讀

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