腺苷脫氨酶

Adenosine deaminase (editase) domain
鑒定
標誌	A_deamin
Pfam（蛋白家族查詢站）	PF02137
InterPro（蛋白數據整合站）	IPR002466
PROSITE（蛋白數據站）	PDOC00419
SCOP（蛋白結構分類數據站）	1add
現有可用的蛋白結構：
Pfam	structures
PDB（蛋白質資料庫）	RCSB PDB; PDBe
PDBsum（蛋白質三維結構站）	structure summary

Adenosine/AMP deaminase
	crystal structure of plasmodium yoelii adenosine deaminase (py02076)
鑒定
標誌	A_deaminase
Pfam（蛋白家族查詢站）	PF00962
Pfam宗系	CL0034
InterPro（蛋白數據整合站）	IPR001365
PROSITE（蛋白數據站）	PDOC00419
SCOP（蛋白結構分類數據站）	1add
現有可用的蛋白結構：
Pfam	structures
PDB（蛋白質資料庫）	RCSB PDB; PDBe
PDBsum（蛋白質三維結構站）	structure summary

腺苷脫氨酶
	; 牛腺苷脫氨酶的絲帶圖。可見中央的鋅離子。來自PDB 1VFL
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	1M7M, 3IAR
標識
代號	ADA;
擴展標識	遺傳學：608958 鼠基因：87916 同源基因：37249 GeneCards: ADA Gene
EC編號	3.5.4.4
基因本體論描述
分子功能	· purine nucleoside binding; · adenosine deaminase activity; · adenosine deaminase activity; · adenosine deaminase activity; · protein binding; · zinc ion binding; · zinc ion binding; · hydrolase activity; · metal ion binding;
細胞成分	· extracellular space; · cytoplasm; · lysosome; · cytosol; · plasma membrane; · external side of plasma membrane; · cell surface; · membrane; · cell junction; · cytoplasmic vesicle; · dendrite cytoplasm; · neuronal cell body; · cytoplasmic membrane-bounded vesicle lumen;
生物過程	· response to hypoxia; · in utero embryonic development; · trophectodermal cell differentiation; · liver development; · placenta development; · germinal center B cell differentiation; · positive regulation of germinal center formation; · negative regulation of leukocyte migration; · negative regulation of mature B cell apoptosis; · purine base metabolic process; · adenosine catabolic process; · adenosine catabolic process; · deoxyadenosine catabolic process; · cell adhesion; · aging; · nucleotide metabolic process; · purine ribonucleoside monophosphate biosynthetic process; · positive regulation of heart rate; · positive regulation of B cell proliferation; · purine nucleotide salvage; · positive regulation of T cell differentiation in thymus; · regulation of cell-cell adhesion mediated by integrin; · T cell activation; · response to hydrogen peroxide; · negative regulation of apoptosis; · purine-containing compound salvage; · regulation of circadian sleep/wake cycle, sleep; · positive regulation of smooth muscle contraction; · dATP catabolic process; · hypoxanthine biosynthetic process; · inosine biosynthetic process; · inosine biosynthetic process; · xanthine biosynthetic process; · positive regulation of alpha-beta T cell differentiation; · lung alveolus development; · Peyer's patch development; · embryonic digestive tract development; · negative regulation of inflammatory response; · positive regulation of calcium-mediated signaling; · positive regulation of T cell receptor signaling pathway; · nucleobase, nucleoside and nucleotide metabolic process; · negative regulation of adenosine receptor signaling pathway; · negative regulation of penile erection; · negative regulation of thymocyte apoptosis; · negative regulation of mucus secretion;
	Sources: Amigo / QuickGO
RNA表達模式
	更多表達數據
直系同源體
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A+醫學百科 >> 腺苷脫氨酶

Adenosine/AMP deaminase N-terminal

鑒定

標誌

A_deaminase_N

Pfam（蛋白家族查詢站）

PF08451

InterPro（蛋白數據整合站）

IPR013659

現有可用的蛋白結構：
Pfam	structures
PDB（蛋白質資料庫）	RCSB PDB; PDBe
PDBsum（蛋白質三維結構站）	structure summary

腺苷脫氨酶（英語：Adenosine deaminase）的是一種參與嘌呤代謝作用的酶。它是用作拆解食物組織中的核酸中的腺苷。

反應

腺苷脫氨酶對腺苷進行不可逆轉的脫氨作用,轉化腺苷為相關的核苷肌苷,移除胺基酸組。

病理學

腺苷脫氨酶的突變基因使之不容易被表達,這是一些免疫缺陷病（ SCID ）的原因。基因突變令ADA被過度產生是溶血性貧血原因之一。有一些證據表明，一個不同的allelle (ADA2)可能會導致自閉症。

參考文獻

深入閱讀

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Valenzuela A, Blanco J, Callebaut C, et al.. HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26. Adv. Exp. Med. Biol.. 1997, 421: 185–92. PMID 9330696.
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Hirschhorn R. Identification of two new missense mutations (R156C and S291L) in two ADA- SCID patients unusual for response to therapy with partial exchange transfusions. Hum. Mutat.. 1993, 1 (2): 166–8. doi:10.1002/humu.1380010214. PMID 1284479.
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