CD4受體
(重定向自CD4)
A+醫學百科 >> CD4受體 |
CD4受體 | |||||||||
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structure of t-cell surface glycoprotein cd4, monoclinic crystal form | |||||||||
鑒定 | |||||||||
標誌 | CD4-extrcel | ||||||||
Pfam(蛋白家族查詢站) | PF09191 | ||||||||
InterPro(蛋白數據整合站) | IPR015274 | ||||||||
SCOP(蛋白結構分類數據站) | 1cid | ||||||||
OPM家族(膜蛋白方向) | 230 | ||||||||
OPM蛋白(膜蛋白方向) | 2klu | ||||||||
CDD(保守域數據站) | cd07695 | ||||||||
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CD4受體,全稱「表面抗原分化簇4受體」(Cluster of Differentiation 4 receptors),是輔助T細胞的表面標記(surface markers)之一,也是輔助T細胞行使其功能的重要受體。當抗原呈遞細胞(主要是巨噬細胞、棘狀細胞及B細胞本身)將外來病菌分解,把抗原與主要組織相容性複合體結合後,呈遞給輔助T細胞(即與輔助T細胞表面的CD4受體結合),輔助T細胞再接著刺激B細胞產生抗體,此即體液性免疫反應的基本過程。
目錄 |
資料
常用單株抗體或代號:T4,Leu3a 主要表達細胞:Tsub,Msub,Thysub T細胞 分子質量(kDa)和結構:gp55(IgSF) 功 能:與MCHn類分子結合,信號轉導,HIV受體
參見
參考文獻
延伸閱讀
- Miceli MC, Parnes JR. Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol.. Advances in Immunology. 1993, 53: 59–122. doi:10.1016/S0065-2776(08)60498-8. ISBN 978-0-12-022453-1. PMID 8512039.
- Geyer M, Fackler OT, Peterlin BM. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1083955/ Structure–function relationships in HIV-1 Nef]. EMBO Rep.. 2001, 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741. PMC 1083955.
- Greenway AL, Holloway G, McPhee DA, et al.. HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. J. Biosci.. 2004, 28 (3): 323–35. doi:10.1007/BF02970151. PMID 12734410.
- Bénichou S, Benmerah A. [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]. Med Sci (Paris). 2003, 19 (1): 100–6. doi:10.1051/medsci/2003191100. PMID 12836198.
- Leavitt SA, SchOn A, Klein JC, et al.. Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm. Curr. Protein Pept. Sci.. 2004, 5 (1): 1–8. doi:10.2174/1389203043486955. PMID 14965316.
- Tolstrup M, Ostergaard L, Laursen AL, et al.. HIV/SIV escape from immune surveillance: focus on Nef. Curr. HIV Res.. 2004, 2 (2): 141–51. doi:10.2174/1570162043484924. PMID 15078178.
- Hout DR, Mulcahy ER, Pacyniak E, et al.. Vpu: a multifunctional protein that enhances the pathogenesis of human immunodeficiency virus type 1. Curr. HIV Res.. 2005, 2 (3): 255–70. doi:10.2174/1570162043351246. PMID 15279589.
- Joseph AM, Kumar M, Mitra D. Nef: "necessary and enforcing factor" in HIV infection. Curr. HIV Res.. 2005, 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
- Anderson JL, Hope TJ. HIV accessory proteins and surviving the host cell. Current HIV/AIDS reports. 2005, 1 (1): 47–53. doi:10.1007/s11904-004-0007-x. PMID 16091223.
- Li L, Li HS, Pa, et al.. Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. Cell Res.. 2006, 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
- Stove V, Verhasselt B. Modelling thymic HIV-1 Nef effects. Curr. HIV Res.. 2006, 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
外部連結
- MeSH(醫學主題詞)上面的CD1+Antigen
- Mouse CD Antigen Chart
- Human CD Antigen Chart
- *Human Immunodeficiency Virus Glycoprotein 120
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參考來源
出自A+醫學百科 「CD4受體」條目 http://cht.a-hospital.com/w/CD4%E5%8F%97%E4%BD%93 轉載請保留此連結
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