香柑內酯

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{{Drugbox | Watchedfields = changed | verifiedrevid = 443419089 | IUPAC_name = 5-methoxy-2''H''-furo[3,2-''g'']chromen-2-one | image = Bergapten.png <!--Clinical data--> | tradename = | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_category = | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_status = Rx-only | routes_of_administration = 口服 <!--Pharmacokinetic data--> | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = <!--Identifiers--> | CASNo_Ref = {{cascite|correct|CAS}} | CAS_number = 484-20-8 | ATC_prefix = D05 | ATC_suffix = BA03 | PubChem = 2355 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2265 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 4FVK84C92X | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07521 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 24171 <!--Chemical data--> | C=12 | H=8 | O=4 | molecular_weight = 216.19 g/mol | smiles = O=C\1Oc3c(/C=C/1)c(OC)c2ccoc2c3 | InChI = 1/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3 | InChIKey = BGEBZHIAGXMEMV-UHFFFAOYAX | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = BGEBZHIAGXMEMV-UHFFFAOYSA-N }} '''香柑内酯'''（'''5-[[甲氧补骨脂素]]'''）是一种存在于香[[柠檬精油]]与其他柑橘属植物精油，<ref>{{cite journal | title = HPLC profile of citrus essential oils from different species and geographic origin | author = Calvarano I., Calvarano M., Gionfriddo F., Bovalo F., Postorino E. | journal = Essenze Derivati agrumari | volume = 65 | pages = 488–502 | year = 1995}}</ref> 以及葡萄柚汁的呋喃[[香豆素]]，属[[补骨脂素]]的[[衍生物]]。<ref>{{cite journal | author = Sakamaki N., Nakazato M., Matsumoto H., Hagino K., Hirata K., Ushiyama H. | title = Contents of furanocoumarins in grapefruit juice and health foods | journal = Journal of the Food Hygienic Society of Japan | year = 2008 | volume = 49 | issue = 4 | pages = 326–331 | doi = 10.3358/shokueishi.49.326 | pmid = 18787320}}</ref> 它是香柠檬精油中引起光敏性（光[[毒性]]）的活性物质。<ref>{{cite journal | title = Elimination of Furocoumarins in Bergamot Peel Oil | author = Francesco Gionfriddo, Enrico Postorino and Giuseppe Calabrò | journal = Perfumer & Flavorist | volume = 29 | year = 2004}}</ref> 目前市面上的香水采用的是不含香柑内酯的香柠檬精油或人工合成的类似香味物质。 医学上香柑内酯与[[长波紫外线]]（UVA）一同用于[[银屑病]]的长波紫外线光化治疗。<ref>{{cite doi|10.1111/j.1365-2133.1979.tb00014.x}}</ref><ref>{{cite pmid|3279089}}</ref> ==参考资料== {{reflist}} {{抗银屑病药}} [[Category:芳香醚]] [[Category:IARC第2A类致癌物质]] ==参考来源== *[http://zh.wikipedia.org/wiki/%E9%A6%99%E6%9F%91%E5%86%85%E9%85%AF 维基百科-香柑内酯]

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