二苯基-4-哌啶甲醇

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{{Chembox | Verifiedfields = changed | verifiedrevid = 458783562 | ImageFile = Azacyclonol.png | ImageSize = | ImageAlt = | ImageName = | ImageFile1 = | ImageSize1 = | ImageAlt1 = | ImageName1 = | ImageFileL1 = | ImageSizeL1 = | ImageAltL1 = | ImageNameL1 = | IUPACName = Diphenyl(piperidin-4-yl)methanol | IUPACNameZh = 二苯基-4-哌啶甲醇 | OtherNames = MER-17, MDL-4,829 | Section1 = {{Chembox Identifiers | CASNo = 115-46-8 | CASNo_Ref = {{cascite|changed|??}} | CASNo_url = | CASNo_Comment = | CASOther ={{CAS|1798-50-1}} ([[盐酸|HCl]]) | PubChem = 15723 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 14952 | ChemSpiderIDOther =<nowiki></nowiki>{{NewLine|[[UNII]]|[http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno{{=}}2MMR990PEM 2MMR990PEM]|table}}<br/>{{NewLine|[[ChEMBL]]|[https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL127508 CHEMBL127508]|table}}{{NewLine}} | SMILES = OC(c1ccccc1)(c2ccccc2)C3CCNCC3 | InChI = 1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2 | InChIKey = ZMISODWVFHHWNR-UHFFFAOYSA-N | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | Beilstein = | Gmelin = | 3DMet = | UNNumber = | EC-number = | EINECS = | ELINCS = | NLP = | ChEBI = | RTECS = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 2MMR990PEM | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 127508 | E_number = | FEMA = | DrugBank = | KEGG = | MeSHName = | IUPHAR_ligand = | ATCCode = }} | Section2 = {{Chembox Properties | Reference = | C=18 | H=21 | N=1 | O=1 | Formula = | MolarMass = 267.37 g/mol | MolarMass_notes = | ExactMass = | MolarMassOther = | Appearance = 白色至浅米色结晶粉末 | Density = | MeltingPt = 160-163 ºC | BoilingPt = 445.5 °C | SublimationConditions = | CriticalPt = | CriticalPt_notes = | Solubility = }} | Section4 = {{NewLine|{{Chembox header}}|治疗考量|table2|{{NewLine|[[治疗产品管理|合法状态]]|{{Unicode|℞}} 处<small>方专用</small>|table}}<nowiki></nowiki>{{NewLine|[[给药途径|途径]]|Oral|table}}}} | Section5 = {{Chembox Pharmacology | Reference = | Bioavail = | AdminRoutes = | Metabolism = | Metabolites = | HalfLife = | ProteinBound = | Excretion = | Licence_EU = | Licence_US = | Legal_status = | Legal_AU = | Legal_CA = | Legal_UK = | Legal_US = | PregCat = | PregCat_AU = | PregCat_CA = | PregCat_DE = | PregCat_UK = | PregCat_US = }} | Section7 = {{Chembox Hazards | Reference = | ExternalMSDS = | wxxfh = {{wxxfh|Xi}} | EUIndex = | EUHarzardSymbol = | EUHSref = | EUClass = | RPhrases ={{R36/37/38}} | SPhrases = {{S24/25}} | RSPhrases = | GHSPictograms = | GHSSignalWord = | HPhrases = | PPhrases = | MainHazards = | IngestionHazard = | InhalationHazard = | EyeHazard = | SkinHazard = | NFPA-H = | NFPA-F = | NFPA-R = | NFPA-O = | FlashPt =142 °C | Autoignition = | ExploLimits = | PEL = | TLV = | MAK = | MELS = | LD50 = | LC50 = | LCt50 = }} | Section8 = {{Chembox Related | OtherAnions = | OtherCations = | OtherFunctn = | Function = | OtherCpds = }} }} '''二苯基-4-哌啶甲醇'''，又称为'''阿扎环醇'''（{{lang-en|Azacyclonol}}）、'''阿扎环醇'''或'''氮杂环醇'''（{{lang-en|Ataractan}}、Calmeran、Frenoton、Frenquel、Psychosan），也有人称它为'''伽玛[[哌苯甲醇]]'''（{{lang-en|γ-pipradol}}），是一种芳香族有机化合物，包含有[[哌啶]]（氮杂环）、苯和醇（羟基）等[[官能基]]，其化学式为C₁₈H₂₁NO，常[[温下]]为固体，外观为白色至浅米色结晶粉末，是一种药物，即所谓的ataractive，是用来减少[[精神病]]患者的[[幻觉]]用的药剂<ref name="pmid13368052">{{Cite journal| author = BRAUN DL, BROWN BB, FELDMAN RG | title = The pharmacologic activity of alpha-(4-piperidyl)-benzhydrol hydrochloride (azacyclonol hydrochloride); an ataractive agent | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 118 | issue = 2 | pages = 153–61 | year = 1956 | month = October | pmid = 13368052 | doi = | url = http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=13368052}}</ref><ref name="isbn3-88763-075-0">{{Cite book| author = Swiss Pharmaceutical Society | title = Index Nominum 2000: International Drug Directory (Book with CD-ROM) | publisher = Medpharm Scientific Publishers | location = Boca Raton | year = 2000 | pages = | isbn = 3-88763-075-0 | oclc = | doi = | url = http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA84&as_brr=3&pg=PA84#v=onepage&q&f=false}}</ref>。它也被称为[[镇静剂]]和[[安定药]]，但这些定义是不准确的，因为它实际上不具备这样的性质。虽然'''二苯基-4-哌啶甲醇'''是哌苯甲醇（[[二苯基]]-2-哌啶[[甲醇]]）的位置[[异构体]]，但他没有使精神兴奋的效果，反而有轻度抑制作用<ref name="pmid13368052"/><ref name="pmid13944436">{{Cite journal| author = FARRANT J | title = Interactions between cocaine, tyramine and noradrenaline at the noradrenaline store | journal = [[British Journal of Pharmacology and Chemotherapy]] | volume = 20 | issue = | pages = 540–9 | year = 1963 | month = June | pmid = 13944436 | pmc = 1703814 | doi = | url = }}</ref>。 == 参考文献 == <references/> {{抗精神病药物}} [[Category:抗精神病药]] [[Category:哌啶]] [[Category:醇]] ==参考来源== *[http://zh.wikipedia.org/wiki/%E4%BA%8C%E8%8B%AF%E5%9F%BA-4-%E5%93%8C%E5%95%B6%E7%94%B2%E9%86%87 维基百科-二苯基-4-哌啶甲醇]

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